Published in 2019

The DiRECT principles: giving Type 2 diabetes remission programmes the best chance of success

M. D. Hopkins1 , R. Taylor2 and M. E. J. Lean3 1 Diabetes UK, Wells Lawrence House, London, 2 Magnetic Resonance Centre, Institute of Cellular Medicine,Newcastle University, Newcastle, and 3 Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

15 October 2019

06 March 2019

Two-year results of the randomised Diabetes Remission Clinical Trial (DiRECT) (Final accepted draft, prior to editing and corrections.)

DiRECT 2 Year Results published on THELANCET.COM website

Professor Michael EJ Lean MD 1*, Wilma S Leslie PhD1, Alison C Barnes PGDip 2, Naomi Brosnahan PGDip1,6, George Thom MSc 1, Louise McCombie BSc1, Carl Peters MB3, Sviatlana Zhyzhneuskaya MD3, Ahmad Al-Mrabeh PhD3, Kieren G Hollingsworth PhD3, Angela M Rodrigues PhD4, Lucia Rehackova PhD4, Professor Ashley J Adamson2 PhD, Professor Falko F Sniehotta PhD4, Professor John C Mathers PhD 5, Hazel M Ross BSc 6, Yvonne McIlvenna MSc7, Paul Welsh PhD8, Sharon Kean9, Professor Ian Ford PhD9, Alex McConnachie PhD9, Claudia-Martina Messow PhD9 , Professor Naveed Sattar FMedSci8, Professor Roy Taylor MD3*

06 March 2019

Published in 2018

Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight-management programme to achieve remission of type 2 diabetes

Xin Y, Davies A, McCombie L, Briggs A, Messow CM, Grieve E, Leslie WS, Taylor R, Lean MEJ. Lancet Diabetes Endocrinol. 2018 Dec 20. pii: S2213-8587(18)30346-2.

21 December 2018

Type 2 diabetes: 5000 patients to test feasibility of “remission service”

Feinmann J. BMJ. 2018 Nov 30;363:k5114. doi: 10.1136/bmj.k5114.

30 November 2018

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

*The DiRECT clinical trial is referenced in this report on page 19, ref 75

Davies MJ, D'Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ, Buse JB. Diabetologia. 2018 Dec;61(12):2461-2498.

09 October 2018

Cell Metabolism - Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for b Cell Recovery

Taylor R, Al-Mrabeh A, Zhyzhneuskaya S, Peters C, Barnes AC, Aribisala BS, Hollingsworth KG, Mathers JC, Sattar N,Lean MEJ. Cell Metab. 2018 Oct 2;28(4):667.

17 August 2018

Published in 2017

Primary care weight-management for type 2 diabetes: the cluster-randomised Diabetes Remission Clinical Trial (DiRECT)

DiRECT 1 Year Results Supplementary Appendix.pdf

*DiRECT 1 Year Results and Appendix documents were updated on the 8th January 2019

DiRECT 1 Year Results published on THELANCET.COM website

Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Stefanetti R, Trenell M, Welsh P, Kean S, Ford I, McConnachie A, Sattar N, Taylor R. Lancet. 2018 Feb 10;391(10120):541-551.

13 December 2017

Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort

Taylor R, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Sattar N, Welsh P, Peters C, Zhyzhneuskaya S, Hollingsworth KG, Al-Mrabeh A, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Kean S, Ford I, McConnachie A,Lean MEJ. Diabetologia. 2018 Mar;61(3):589-598. Epub 2017 Nov 30

25 October 2017

Beating type 2 diabetes into remission

This was featured in the print edition of the bmj magazine published on the 16th September 2017. Clicking on the image will take you to the online version of the article hosted at, which also includes a link at the top of the page to a podcast discussing diabetes remission.

McCombie L, Leslie W, Taylor R, Kennon B, Sattar N,Lean MEJ. BMJ. 2017 Sep 13;358.

The BMJ - Lighten the load cover

13 September 2017

Published in 2016

Weight losses with low-energy formula diets in obese patients with and without T2D

Leslie WS, Taylor R, Harris L, Lean ME Int J Obes (Lond). 2016 ;1-6.

06 December 2016

The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial

Leslie WS, Ford I, Sattar N, Hollingsworth KG, Adamson A, Sniehotta FF, McCombie L, Brosnahan N, Ross H, Mathers JC, Peters C, Thom G, Barnes A, Kean S, McIlvenna Y, Rodrigues A, Rehackova L, Zhyzhneuskaya S, Taylor R, Lean ME. BMC Fam Pract. 2016;17:20.

16 February 2016