Publications

Published in 2021


Participant experiences in the Diabetes REmission Clinical Trial (DiRECT)

Diabetic Medicine 2021

Lucia Rehackova, Angela Margarete Rodrigues, George Thom, Naomi Brosnahan, Alison C. Barnes, Louise McCombie, Wilma S. Leslie, Sviatlana Zhyzhneuskaya, Carl Peters, Ashley J.Adamson, Michael E. J. Lean, Roy Taylor, Falko F. Sniehotta

14 September 2021


Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT)

Diabetologia (2021)

Wilma S. Leslie & Eman Ali & Leanne Harris & C. Martina Messow & Naomi T. Brosnahan & George Thom & E. Louise McCombie & Alison C. Barnes & Naveed Sattar & Roy Taylor & Michael E. J. Lean

2 June 2021


Brief formula low-energy-diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT)

Journal of Human Nutrition and Dietetics (2021)

Naomi Brosnahan, Wilma Leslie, Louise McCombie, Alison Barnes, George Thom, Alex McConnachie, Claudia Martina Messow, Naveed Sattar, Roy Taylor Michael E. J. Lean

6 January 2021

Published in 2020


Weight loss-induced increase in fasting ghrelin concentration is a predictor of weight regain: Evidence from the Diabetes Remission Clinical Trial (DiRECT)

Diabetes Obes Metab (2020)

George Thom, Alasdair McIntosh, Claudia-Martina Messow, Wilma S. Leslie, Alison C. Barnes, Naomi Brosnahan, Louise McCombie,Dalia Malkova,Ahmad Al-Mrabeh, Sviatlana Zhyzhneuskaya,Paul Welsh, Naveed Sattar,Roy Taylor, Michael E. J. Lean,

2 December 2020


2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial

Lancet Diabetes and Endocrinology (2020)

Ahmad Al-Mrabeh, Kieren G Hollingsworth, James A M Shaw, Alex McConnachie, Naveed Sattar, Michael E J Lean, Roy Taylor*

5 October 2020


Predictors of type 2 diabetes remission in the Diabetes Remission Clinical Trial (DiRECT)

Diabetic Medicine (2020)

G. Thom, C.-M. Messow, W. S. Leslie,A. C. Barnes, N. Brosnahan, L. McCombie, A. Al-Mrabeh, S. Zhyzhneuskaya, P. Welsh, N. Sattar,R. Taylor, M. E. J. Lean,

25 August 2020


Time course of normalization of functional β-cell capacity in the Diabetes Remission Clinical Trial after weight loss in type 2 diabetes

Journal Name - Diabetes Care

Zhyzhneuskaya, S. V., Al-Mrabeh, A., Peters, C., Barnes, A., Aribisala, B., Hollingsworth, K. G., McConnachie, A., Sattar, N., Lean, M. E.J., and Taylor, R.

08 September 2020


Hepatic lipoprotein export and remission of human type 2 diabetes after weight loss

Journal Name - Cell Metabolism

Al-Mrabeh, A., Zhyzhneuskaya, S. V., Peters, C., Barnes, A. C., Melhem, S., Jesuthasan, A., Aribisala, B., Hollingsworth, K. G., Lietz, G., Mathers, J. C., Sattar, N., Lean, M. E.J., and Taylor, R.

08 September 2020


Predictors of type 2 diabetes remission in the Diabetes Remission Clinical Trial (DiRECT)

G. Thom, C.-M. Messow, W. S. Leslie, A. C. Barnes, N. Brosnahan, L. McCombie, A. Al-Mrabeh, S. Zhyzhneuskaya, P. Welsh, N. Sattar, R. Taylor and M. E. J. Lean

02 September 2020


Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/Counterweight-Plus weight management programme

Diabetologia, 63(10), 2112-2122.
DOI 10.1007/s00125-020-05224-2

Yiqiao Xin1 & Andrew Davies1 & Andrew Briggs2 & Louise McCombie3 & C. Martina Messow4 & Eleanor Grieve1 & Wilma S. Leslie3 & Roy Taylor5 & Michael E. J. Lean3

19 May 2020

Published in 2019


The DiRECT principles: giving Type 2 diabetes remission programmes the best chance of success

M. D. Hopkins1 , R. Taylor2 and M. E. J. Lean3 1 Diabetes UK, Wells Lawrence House, London, 2 Magnetic Resonance Centre, Institute of Cellular Medicine,Newcastle University, Newcastle, and 3 Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

15 October 2019


06 March 2019


Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial.

DiRECT 2 Year Results published on THELANCET.COM website

Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Welsh P, Kean S, Ford I, McConnachie A, Messow CM, Sattar N, Taylor R.

06 March 2019


Published in 2018


Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight-management programme to achieve remission of type 2 diabetes

Xin Y, Davies A, McCombie L, Briggs A, Messow CM, Grieve E, Leslie WS, Taylor R, Lean MEJ. Lancet Diabetes Endocrinol. 2018 Dec 20. pii: S2213-8587(18)30346-2.

21 December 2018


Type 2 diabetes: 5000 patients to test feasibility of “remission service”

Feinmann J. BMJ. 2018 Nov 30;363:k5114. doi: 10.1136/bmj.k5114.

30 November 2018


Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

*The DiRECT clinical trial is referenced in this report on page 19, ref 75

Davies MJ, D'Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ, Buse JB. Diabetologia. 2018 Dec;61(12):2461-2498.

09 October 2018


Cell Metabolism - Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for b Cell Recovery

Taylor R, Al-Mrabeh A, Zhyzhneuskaya S, Peters C, Barnes AC, Aribisala BS, Hollingsworth KG, Mathers JC, Sattar N,Lean MEJ. Cell Metab. 2018 Oct 2;28(4):667.

17 August 2018


Published in 2017


Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.

DiRECT 1 Year Results published on THELANCET.COM website

Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Stefanetti R, Trenell M, Welsh P, Kean S, Ford I, McConnachie A, Sattar N, Taylor R.

13 December 2017


Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort

Taylor R, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Sattar N, Welsh P, Peters C, Zhyzhneuskaya S, Hollingsworth KG, Al-Mrabeh A, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Kean S, Ford I, McConnachie A,Lean MEJ. Diabetologia. 2018 Mar;61(3):589-598. Epub 2017 Nov 30

25 October 2017


Beating type 2 diabetes into remission

This was featured in the print edition of the bmj magazine published on the 16th September 2017. Clicking on the image will take you to the online version of the article hosted at www.bmj.com, which also includes a link at the top of the page to a podcast discussing diabetes remission.

McCombie L, Leslie W, Taylor R, Kennon B, Sattar N,Lean MEJ. BMJ. 2017 Sep 13;358.

The BMJ - Lighten the load cover

13 September 2017


Published in 2016


Weight losses with low-energy formula diets in obese patients with and without T2D

Leslie WS, Taylor R, Harris L, Lean ME Int J Obes (Lond). 2016 ;1-6.

06 December 2016


The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial

Leslie WS, Ford I, Sattar N, Hollingsworth KG, Adamson A, Sniehotta FF, McCombie L, Brosnahan N, Ross H, Mathers JC, Peters C, Thom G, Barnes A, Kean S, McIlvenna Y, Rodrigues A, Rehackova L, Zhyzhneuskaya S, Taylor R, Lean ME. BMC Fam Pract. 2016;17:20.

16 February 2016